Patents and Publications

At Edna, we are committed to helping our customers break barriers in science by providing a portfolio of innovative, top-quality and affordable products.

Our core research and product development team has a range of patents and publications which are the foundation of our company's technical expertise.


  1. Rathore, A. S., Nigam, K.D.P., Pathak, M., Kateja, N., Hebbi, V., Sharma, A. K., Agarwal, H., Coiled flow inverter as a reactor for biotech unit operations. (2016). WIPO Application No: WO2016116947A1

  2. Rathore, A.S., Hebbi, V, Pandi, K., Gomes, J., Claire. K. (2019). Process for Producing Peptide. PCT Application No: PCT/IN2019/050471

  3. Rathore, A.S., Hebbi, V, Thakur, G., Savane, T. (2019). Real Time Monitoring of Protein and Excipients. Indian Patent Application No: 202011007820

  4. Rathore, A.S., Hebbi, V, Thakur, G. (2019). A System for Monitoring and Control of Chromatography. Indian Patent Application No: 201911011227. PCT Application No: PCT/IN2020/050264.

  5. Rathore, A.S., Kateja, N, Nitika. (2019). A novel process for preparation of pegylated recombinant therapeutic products. Indian Provisional Patent Application No: 201911049731

  6. Rathore, A.S.,Thakur, G., Saxena, N., Tiwari, A. (2020). Surge Tank Based System for Automated Operation and Control of Continuous Biopharmaceutical Manufacturing. Indian Patent Application No: 202011034558


  1. Hebbi, V., Thakur, G., & Rathore, A. S. (2019). Process analytical technology implementation for protein refolding: GCSF as a case study. Biotechnology and bioengineering, 116(5), 1039-1052.

  2. Thakur, G., Hebbi, V., & Rathore, A. S. (2019). An NIR based PAT tool for real-time control of loading in Protein A chromatography in continuous manufacturing of monoclonal antibodies, Biotechnology and Bioengineering, vol. 117, no. 3, pp. 673–686, Dec. 2019, doi: 10.1002/bit.27236.

  3. Hebbi, V., Pandi, K., Kumar, D., Komives, C., & Rathore, A. S. (2018). Process for production and purification of lethal toxin neutralizing factor (LTNF) from E. coli and its economic analysis. Journal of Chemical Technology & Biotechnology, 93(4), 959-967.

  4. Kateja, N., Agarwal, H., Hebbi, V., & Rathore, A. S. (2017). Integrated continuous processing of proteins expressed as inclusion bodies: GCSF as a case study. Biotechnology progress, 33(4), 998-1009.

  5. Hebbi, V., Chattopadhyay, S., & Rathore, A. S. (2019). High performance liquid chromatography (HPLC) based direct and simultaneous estimation of excipients in biopharmaceutical products. Journal of Chromatography B, 1117, 118-126.

  6. Hebbi, V., Shukla, A., & Rathore, A. S. (2018). Modeling and prediction of excipient and pH drifts during ultrafiltration/diafiltration of monoclonal antibody biotherapeutic for high concentration formulations, Separation and Purification Technology, vol. 238, p. 116392, May 2020.

  7. Kateja, N., Kumar, D., & Rathore, A. S. (2018). Continuous Non-Protein A Purification Platform for Monoclonal Antibody Therapeutics. Journal of chromatography, 1579, 60-72.

  8. Kateja, N., Kumar, D., Godara, A., Kumar, V., & Rathore, A. S. (2017). Integrated Chromatographic Platform for Simultaneous Separation of Charge Variants and Aggregates from Monoclonal Antibody Therapeutic Products. Biotechnology Journal, 12(11), 32-35.

  9. Kateja, N., Agarwal, H., Saraswat, A., Bhat, M., & Rathore, A. S. (2016). Continuous precipitation of process related impurities from clarified cell culture supernatant using a novel coiled flow inversion reactor (CFIR). Biotechnology journal, 11(10), 1320-1331.

  10. Tiwari, A., Kateja, N., Chanana, S., & Rathore, A. S. (2018). Use of HPLC as an enabler of process analytical technology in process chromatography. Analytical chemistry, 90(13), 7824-7829.

  11. Thakur, G,. Hebbi, V., Parida, S. and Rathore, A. S. (2020) Automation of Dead End Filtration: An Enabler for Continuous Processing of Biotherapeutics. Front. Bioeng. Biotechnol. 8:758.

  12. Thakur, G., Thori, S., & Rathore, A. S. (2020). Implementing PAT for single-pass tangential flow ultrafiltration for continuous manufacturing of monoclonal antibodies. Journal of Membrane Science, 613, 118492.

  13. Kateja, N., Nitika, Dureja, S., & Rathore, A. S. (2020). Development of an integrated continuous PEGylation and purification Process for granulocyte colony stimulating factor. Journal of Biotechnology, 322, 79–89.