Trypsin is a serine protease from bovine pancreas that cleaves at the carboxylic side of lysine and arginine residues. Edna trypsin for in-process applications is highly specific as it is purified by ion exchange chromatography, modified by reductive methylation to prevent auto-cleavage, and TPCK-treated to inactivate any remaining chymotrypsin activity.

Carboxypeptidase B (CPB) is a pancreatic endo-peptidase that cleaves C-terminal basic residues, particularly Arg and Lys. Edna CPB products are well-suited for characterization applications such as analysis of mAb basic variants, and for process applications such as insulin cleavage or reduction of heterogeneity in mAb material.

Chymotrypsin is a serine protease from bovine pancreas that cleaves at the carboxylic side of aromatic tyrosine, phenylalanine and tryptophan residues. It is highly purified by ion exchange chromatography for best specificity for sequencing. It is also well-suited for in-process applications such as multimer cleavage.